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intermediates
key building blocks to optimize your active pharmaceutical ingredients
We provide material solutions for your pharmaceutical processing needs. Our intermediate portfolio includes key building blocks such as API precursors, catalysts, reagents, and solvents.
API precursors
3,5-Lutidine
3,5-Lutidine is the precursor for the active ingredients in the drugs Omeprazol and Esomeprazole. These drugs, popularized under trademarked brand names such as Prilosec and Nexium, are proton pump inhibitors that decrease the amount of acid produced by the stomach. They are proven treatments for conditions where there is too much acid in the stomach, such as dyspepsia, heartburn, indigestion, ulcers, and acid reflux.
2-Vinylpyridine
2-Vinylpyridine is the key intermediate in the production of the API, Betahistine. Betahistine is an anti-vertigo medicine commonly prescribed for balance disorders and helps to alleviate dizziness. When compared to standard grades of 2-Vinylpyridine, our high-purity 2-VP HP meets more stringent specifications for purity and assay, which are key for use in pharmaceutical intermediates.
3-Aminopyridine
3-Aminopyridine is a useful building block in small molecule synthesis for APIs, including in the production of Linagliptin for the treatment of diabetes. Linagliptin is in a class of medications known as dipeptidyl peptidase-4 inhibitors, which function by increasing certain natural substances to help lower blood sugar.
catalysts
Easy-Flo™ Catalyst
Easy-Flo (DMAP) is used in the synthesis of many pharmaceuticals. It is a well-known acylation catalyst that improves yields and throughput by increasing reaction rates and suppressing unwanted side reactions, leading to higher quality end products.
Our Easy-Flo is the only DMAP available in prilled form; all other DMAP manufacturers and suppliers use a powder form. Our prilled (pellet) form offers an easier and safer handling experience across the supply chain.
reagents
Piperidine
Piperidine is useful as a reagent in peptide synthesis, as it prevents unwanted side reactions in the peptide sequence and promoting amino acid coupling. Peptide-based therapies are highly specific and recognized for their safety, efficacy, and patient tolerance. They find broad pharmaceutical applications including in metabolic diseases and oncology. We also offer Pyridine.
solvents
2,6-Lutidine
2,6-Lutidine is a dimethyl-substituted derivative of pyridine used as a solvent in the preparation of antibiotics and a key building block in the development of both drugs and APIs. As the largest producer of 2,6-Lutidine globally along with our continuous production and distillation technology, we offer consistent quality as well as specialized high-purity and super dry grades. Other solvents we offer include Alpha Picoline and Pyridine.
active pharmaceutical ingredient
healthcare treatment for Wilson’s disease
Wilson’s disease is a rare disorder that causes copper to accumulate in the liver, brain, and other vital organs. Symptoms of Wilson’s disease include swelling, abdominal pian, fatigue, and jaundice. When the active pharmaceutical ingredient (API) Zinc Acetate is used in therapeutic treatment, it inhibits the body’s absorption of copper.
